Automated Synthesis of Cyclic Peptides on Biotage® Initiator+ Alstra™

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We have demonstrated the capability of the Biotage® Initiator+ Alstra™ microwave peptide synthesizer to fully automate the on-resin synthesis of cyclic peptides with examples showing disulfide bridge formation and side-chain to side-chain cyclization respectively. The synthesis included specialized reactions of non-linear peptides which were achieved with a high degree of purity. Furthermore, this was achieved using the unique Branches™ tool which provides an extensive overview for the scheduling and visualization of operations in order to simplify the programming of complex peptide modifications and is a great addition to the toolbox for the peptide chemist.