Welcome to the Biotage Flash Purification Blogs.

      Are you in control of your Flash Purification?

      January 29, 2019 at 10:33 AM / by Greg Saunders posted in Biotage, flash chromatography, Flash column chromatography, column chromatography, column chromatography method, flash purification


      Learn more about how to get in control of your Flash Purification.

      With Biotage® Selekt and Sfär chemists can be in full control of Flash Purification. 
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      Dry loading vs. liquid loading, which provides better flash column chromatography results?

      January 23, 2019 at 2:15 PM / by Bob Bickler posted in flash chromatography, silica column, automated chromatography system, sfär


      When it comes time to purify your reaction mixture or natural product extract, you have a choice to make. Should you simply load your dissolved sample onto your flash column or take the extra step to adsorb your mix onto a sorbent and dry it before loading? The choice can have a major impact on your results.

      In this post, I will share results of work I conducted in my lab, comparing liquid and dry loading a reaction mixture that containing eight major components.

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      Are there benefits to collecting flash chromatography fractions based on multiple UV wavelengths?

      January 8, 2019 at 7:29 PM / by Bob Bickler posted in UV Detection, Selekt


      UV detection and fractionation is ubiquitous in flash chromatography. It is the default methodology used to detect and collect eluting compounds. Today’s flash chromatography systems offer UV-triggered fractionation on one, two, or a range of wavelengths in order to either increase fractionation specificity, yield, or increase sensitivity. In this post, I will discuss the value of incorporating fractionation based on a wavelength range and two selectable individual wavelengths.

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