Welcome to the Biotage Flash Purification Blogs.

      Are so-called “high performance” flash columns worth their higher prices?

      March 19, 2019 at 10:05 PM / by Bob Bickler posted in resolution, particle size, surface area

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      Most flash column manufacturers now offer “high performance” flash chromatography columns with the promise of higher loading, increased purity, and even reduced solvent consumption. Working for Biotage, I have made those valid claims for our products as well.

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      Webinar: A Roadmap to Successful Chromatography

      March 19, 2019 at 10:00 PM / by Bob Bickler posted in Flash column chromatography, flash purification, column chromatography lab, webinar

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      On July 26th, 2018, Bob Bickler, Senior Technical Specialist, recorded a webinar on A Roadmap to Successful Flash Chromatography. To learn more, read the description below as well as watch the recording!

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      The three reasons you should be using step gradients for flash column chromatography

      March 5, 2019 at 9:34 PM / by Bob Bickler posted in linear gradient, normal phase, step-gradient, greener flash purification

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      For most synthesis and natural product chemists, flash chromatography is the primary tool for purification and isolation of compounds of interest. Purification methods include flash system defaulted linear gradients (e.g. 0-100%), active gradient modification (on-the-fly) during purification, and unique method creation based one either the chemist’s experience or TLC data (typically a linear gradient). Rarely do chemists work to optimize the purification to maximize target compound purity by employing a step gradient. In this post, I discuss the value optimized step gradients provide chemists.

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