Welcome to the Biotage Flash Purification Blogs.

    What are alternatives to DCM/MeOH for polar reaction mix purifications?

    August 24, 2021 at 6:00 PM / by Bob Bickler posted in Solvents, Green, purification

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    For most chemists purifying organic reaction mixtures, normal-phase flash chromatography is the go-to technique. Why not, it is quick, relatively efficient, and can provide relatively high loading capacities if the separation is properly optimized. However, most of these same chemists rely on only two sets of solvents to perform these purifications…

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    How does an acid pH affect reversed-phase chromatography separations?

    August 10, 2021 at 6:00 PM / by Bob Bickler posted in Reversed-phase, acid, pH

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    Chromatography is as much an art as it is a science. Between synthetic reaction products and natural products, the range of compounds requiring separation, purification, and isolation is broad and diverse creating challenges from time to time. Because of this diversity, not all chromatographic separations can be performed with a “neutral” solvent system – one without added pH modifiers or buffers.

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