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Does reagent and reaction solvent order impact product yield and purity?

October 19, 2021 at 6:00 PM / by Bob Bickler


This is a question I asked myself while I have been studying synthesis variables to see what, if any, impact each variable has on reaction product yield and purity. For this post, I evaluated the order in which I added reactants and solvent.

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Can maximizing product yield and purity from messy reaction mixture be green?

October 5, 2021 at 8:42 PM / by Bob Bickler

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Chemical reactions gone wrong, I’m sure we all have experienced this issue, I know I have. You add your reagents in the proper amounts with a suitable solvent and perform your reaction only to find your by-product yield was greater than your product; by a lot. So, what do you do to isolate what little product you created with maximum yield and purity without breaking the proverbial bank on a big flash column and the solvent required for the purification?

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