Welcome to the Biotage Flash Purification Blogs.

    How does reaction time impact synthetic product purity and yield?

    November 30, 2021 at 4:59 PM / by Bob Bickler posted in Reversed-phase, Normal Phase, microwave

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    For my purification blog I often will synthesize compounds so I can show representative, real-world reaction product purification. In doing so, I decided I would also post on the impact of various synthesis variable. This post looks at the impact of reaction temperature time on an amide synthesis.

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    Can Reaction Temperature Impact Synthetic Product Yield and Purity?

    November 17, 2021 at 7:01 PM / by Bob Bickler posted in reaction, flash chromatography

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    Though this is a purification blog I do, from time to time, like to address synthetic chemistry experimentation findings in the desire to assist you with your reactions, as this is the front-end of your synthesis workflow. So, in this post, I report on some findings of the effect of reaction temperature on the synthesis of an amide, 2-amino-N-benzylbenzamide, a potential antibacterial compound[1].

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    Can reversed-phase flash chromatography compete with prep-HPLC?

    November 2, 2021 at 3:58 PM / by Bob Bickler posted in Reversed-phase, HPLC

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    Flash chromatography competing with prep-HPLC? Why and when would flash outperform or even be equal to prep HPLC? Well, it depends on your purification needs and goals.

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