Reversed-phase flash chromatography use continues to increase for a variety of reasons. Unlike silica normal-phase flash columns, which typically are used only once, reversed-phase flash columns can be cleaned, stored, and reused. How many times can a column be reused is a frequent question I receive. In this post, I will do my best to answer this question.

As you know, reaction chemistry involves determining and selecting the right conditions for optimal product yield and purity. There are actually six variables, that I know of, needing consideration including…