Welcome to the Biotage Flash Purification Blogs.

    How to maximize UV detection sensitivity in flash chromatography

    June 21, 2022 at 4:11 PM / by Bob Bickler posted in Solvents, UV, wavelength, sensitvity

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    Automated flash chromatography has become an integral component of the workflows of both synthetic organic chemistry and natural product research. The most utilized chromatographic technique is normal-phase, which uses a polar stationary phase filled column (i.e. silica) and a mix of non-polar and moderately polar solvents, i.e. hexane or heptane and ethyl acetate (EtOAc), resp.

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    How to isolate impurities from a reaction product

    June 7, 2022 at 5:57 PM / by Bob Bickler posted in reaction, orthogonal, by-product, impuriity

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    Ensuring that the product of a reaction is pure is critical to that compound’s viability as a marketable entity. Impurities often require characterization if they are in excess of regulated limits. The isolation of these compounds can be quite challenging. 

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