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What should I use instead of DCM/MeOH flash chromatography for purification?

March 28, 2023 at 2:00 PM / by Bob Bickler

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While polar compound purification is frequently performed using a silica column and a DCM/MeOH solvent system, there is a need to reduce its use in chromatography for a number of reasons. First, dichloromethane (DCM) is categorized as a health hazard (neurotoxin[1]) and likely carcinogen (per the US EPA). If that isn’t a good enough reason, DCM is not environmentally friendly carrying a large carbon footprint and being a greenhouse gas[2].

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How to improve synthesis workflow by over 90%

March 14, 2023 at 2:00 PM / by Bob Bickler

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Synthesis workflow is the journey taken by chemists when creating a molecule. This journey can be like taking the interstate with no traffic lights and higher speed limits but usually this trip is more like taking backroads with slower speeds, stop signs, and sometimes detours. I believe most chemists prefer the highway rather than the local route but perhaps don’t have the infrastructure to get to their destination as efficiently as desired.

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