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    Which solvent is better for reversed-phase flash chromatography - methanol or acetonitrile?

    January 26, 2021 at 1:49 PM / by Bob Bickler posted in Chromatography Fundamentals, acetonitrile, methanol, selectivity


    An interesting question for synthesis chemists as the need for reversed-phase flash chromatography for both intermediates and final compounds increases. Historically, normal-phase flash chromatography has been the “go-to” purification tool for synthetic intermediates. Today, however, intermediates and final products are increasingly polar. These polar reaction mixtures cause purification challenges in both separation and recovery with normal-phase (silica) thus requiring use of reversed-phase flash chromatography.

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