Welcome to the Biotage Flash Purification Blogs.

    Six key factors that impact flash chromatography

    October 18, 2019 at 9:54 PM / by Bob Bickler posted in Chromatography Fundamentals, Solvents, Sfär, Media and Resin, Automation, Cost


    In this post I will delve into six key factors that impact your purification success in flash column chromatography.

    Previously, I have discussed the use of TLC for solvent scouting and method development and optimization. I have have also talked about cartridge size, particle size, and surface area and their impact on flash purification.  Here I integrate that information into the six factors below.

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    How tools such as flash column chromatography boost confidence in drug discovery

    September 26, 2018 at 3:54 PM / by Kathryn Lawrence posted in Workflow, Green, Sfär, Selekt, Automation, Cost


    New drug substances, the result of more than a decade of pharmaceutical research and development,  have revolutionized society by saving lives, increasing life-spans, reducing suffering, avoiding surgery, and shortening hospital stays. New breakthroughs in the treatment of non-communicable diseases mean that drug substances are in a constant state of high demand, making the pharmaceutical industry one of the most innovative of industries on the globe. Why then, do so few drugs come to market? It turns out that a key factor is providing drug discovery chemists with tools such as automated flash chromatography to ensure that they can be confident in delivering target compounds in a timely fashion.

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    Automated flash column chromatography helps to make chemistry more fun

    September 19, 2018 at 11:12 AM / by John Urh posted in Selekt, Automation


    Isn’t amazing chemistry what you want to do every day? Don’t you strive for white crystalline final products? But things get in the way, such as other priorities, endless emails and frequent interruptions to your synthetic flow.  Not to mention the challenges of designing new synthetic strategies, creating what could be the world’s most impactful new molecular entity. Finding the right reaction, the right reagents. Finding a way to get around yet another dead end. But those challenges are why you got into chemistry in the first place, right? After all, if it was easy, anyone could do it and you’re not just anyone. So let’s look at a few things that can put the fun back into chemistry.

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