Welcome to the Biotage Flash Purification Blogs.

      How does solvent choice impact reversed-phase flash chromatography separations?

      October 4, 2019 at 6:30 PM / by Bob Bickler posted in Cannabis, Chromatography, Gradient, Normal phase, Optimization, SNAP, Solvents, Troubleshooting, Selekt, Media, Mass-directed purification, Theory

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      I have recently posted on how solvent choice influences the separation of hard to resolve compounds using normal-phase flash chromatography. As a chemist with an inquiring mind, I thought I would expand my research beyond normal-phase and see what happens in reversed-phase.

      In this post, I share my results. 

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      How can I rapidly remediate THC from CBD in my hemp extract using flash column chromatography?

      September 20, 2019 at 2:52 PM / by Bob Bickler posted in Cannabis, Gradient, Remediation, Reversed-phase, Troubleshooting

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      Tetrahydrocannabinol, aka THC, is a hallucinogen found in cannabis and, to a lesser degree, in hemp.  Though THC is legal in some locations in the US and Canada, there is a growing market for its non-hallucinogenic cousin, cannabidiol (CBD), which has purported medical benefits.

      The problem with isolating CBD from cannabis and hemp is contamination from THC, which is typically present at a moderate to high percentage. In this post, I will provide some insight into rapidly purifying CBD to remove THC.

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      Pesticide remediation of Cannabis oil - Myclobutanil removal by flash chromatography

      June 11, 2019 at 3:51 PM / by Brian Wagner posted in Cannabis, Chromatography, Reversed-phase

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      Welcome to a second installment of the Biotage Cannabis Application development flash blog.  The first post, dated August 20  2016, outlined an orthogonal approach to isolating cannabinoids from winterized extract.  Give it read if you have not seen it

      Today we investigate the “hot” topic of pesticide elimination from extract.  Specifically – Myclobutanil remediation.

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      Minor Cannabinoid Separation by Reversed-phase Flash Chromatography

      May 17, 2019 at 8:30 PM / by Bob Bickler posted in Cannabis, Chromatography, Optimization, Reversed-phase

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      Previously, I have posted on a normal-phase flash chromatography method to separate and isolate CBG from a CBD-rich hemp distillate. CBG is just one of many naturally occurring minor cannabinoids of interest in this fast-growing market.

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      Isolation of some minor cannabinoids using flash chromatography

      April 16, 2019 at 11:02 PM / by Bob Bickler posted in Cannabis, Optimization

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      Cannabis entrepreneurs continually seek to differentiate themselves from others in the market. Some focus on THC while others focus on CBD. What I have seen recently after attending some cannabis-specific conferences is a growing interest in isolating/purifying some of the minor, naturally occurring phytocannabinoids such as CBG and CBDV.

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