Welcome to the Biotage Flash Purification Blogs.

      Are you in control of your Flash Purification?

      January 29, 2019 at 10:33 AM / by Greg Saunders posted in Biotage, flash chromatography, Flash column chromatography, column chromatography, column chromatography method, flash purification

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      Learn more about how to get in control of your Flash Purification.

      With Biotage® Selekt and Sfär chemists can be in full control of Flash Purification. 
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      Building greener separations into the flash workflow

      November 20, 2018 at 3:01 PM / by Greg Saunders posted in greener flash purification, Flash column chromatography, column chromatography method, flash purification

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      The synthesis of new chemical entities certainly has a high environmental cost due to the chemicals employed, especially in flash column chromatography, where large quantities of solvents are routinely used. The previous article in this series presented three strategies that can greatly reduce the environmental impact of your flash purifications: (1) purifying more product with less silica, and solvent, (2) making green chemistry work for you, such as changing to more environmentally friendly solvents, and (3) optimizing chromatography with more effective step gradients. Let’s look at how new developments in column design, simplifications in step gradients, and support from a leader in flash column chromatography can help in making your operation greener.

       

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      Make researching new chemistries more fun with the right automated flash column chromatography system

      November 5, 2018 at 10:00 AM / by John Urh posted in Flash column chromatography, automated chromatography system, column chromatography method, flash purification

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      As we saw in a previous article, the most critical and time-consuming part of organic chemistry synthesis is the purification step. Running a column, testing the resulting fraction, and maybe re-running columns takes too much time – time you could use to prepare reactions or research new chemistries. What if your laboratory equipment made it easier for you to focus on amazing khemistry? Let’s find out what is possible with the latest in automated flash column chromatography systems. 
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      How tools such as flash column chromatography boost confidence in drug discovery

      September 26, 2018 at 3:54 PM / by Kathryn Lawrence posted in column chromatography procedure, pharmaceutical research, silica column, automated chromatography system, column chromatography method, flash purification, column chromatography lab

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      New drug substances, the result of more than a decade of pharmaceutical research and development,  have revolutionized society by saving lives, increasing life-spans, reducing suffering, avoiding surgery, and shortening hospital stays. New breakthroughs in the treatment of non-communicable diseases mean that drug substances are in a constant state of high demand, making the pharmaceutical industry one of the most innovative of industries on the globe. Why then, do so few drugs come to market? It turns out that a key factor is providing drug discovery chemists with tools such as automated flash chromatography to ensure that they can be confident in delivering target compounds in a timely fashion.

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      Automated flash column chromatography helps to make chemistry more fun

      September 19, 2018 at 11:12 AM / by John Urh posted in flash chromatography, Flash column chromatography, column chromatography, column chromatography procedure, pharmaceutical research, silica column, automated chromatography system, column chromatography method

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      Isn’t amazing chemistry what you want to do every day? Don’t you strive for white crystalline final products? But things get in the way, such as other priorities, endless emails and frequent interruptions to your synthetic flow.  Not to mention the challenges of designing new synthetic strategies, creating what could be the world’s most impactful new molecular entity. Finding the right reaction, the right reagents. Finding a way to get around yet another dead end. But those challenges are why you got into chemistry in the first place, right? After all, if it was easy, anyone could do it and you’re not just anyone. So let’s look at a few things that can put the fun back into chemistry.

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