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      Dry loading vs. liquid loading, which provides better flash column chromatography results?

      January 23, 2019 at 2:15 PM / by Bob Bickler posted in de-banding, flash chromatography, silica column, automated chromatography system, sfär


      When it comes time to purify your reaction mixture or natural product extract, you have a choice to make. Should you simply load your dissolved sample onto your flash column or take the extra step to adsorb your mix onto a sorbent and dry it before loading? The choice can have a major impact on your results.

      In this post, I will share results of work I conducted in my lab, comparing liquid and dry loading a reaction mixture that containing eight major components.

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