Welcome to the Biotage Flash Purification Blogs.

      Is there an easy way to purify organic amines?

      April 11, 2019 at 9:35 AM / by Bob Bickler posted in Amine, base, dichloromethane, heterocyclic


      If you synthesize organic amine compounds, especially heterocyclic, secondary, or tertiary amines, you likely have encountered problems with their chromatography using silica columns. With the amine groups being basic and silica being acidic, there is a natural attraction between the two. This sometimes strong attraction often requires the use of a competing amine in the solvent system. Modification of the mobile phase with the addition of a solvent like triethyl amine can provide a successful purification. Often times the use of an amine-modified stationary phase can provide the needed conditions to avoid the acid-base interaction that can interfere with a successful flash chromatography purification.

      In this post I will discuss how amine-functionalized silica can simplify organic amine purification and your life (at least in the lab).

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      Does methanol really dissolve silica during flash column chromatography?

      April 9, 2019 at 11:23 PM / by Bob Bickler posted in Developments, methanol, dichloromethane, dissolve


      This is an age-old question that has been around a long time, perhaps as long as me (and I have been around a while) –  “Does silica dissolve in methanol?”

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