Welcome to the Biotage Flash Purification Blogs.

      How do I purify my high boiling solvent reaction mixture using silica flash chromatography?

      October 18, 2019 at 9:48 PM / by Bob Bickler posted in solvent, dissolve, purify, boiling point


      Many chemists today find they need to synthesize molecules at higher temperatures in order to force difficult reactions to proceed. Solvents such as DMF, DMSO, and NMP are commonly used in these reactions as they facilitate the use of the high reaction temperatures.  However, the same attributes that make these chemicals attractive as reaction solvents make compound recovery from them very difficult, including flash column chromatography.  These high boiling solvents are typically polar and pose a challenge if purification is to be accomplished with normal-phase silica.

      In this post I explore some options that enable purification of high boiling point solvated reaction mixtures through simple sample work-up.

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      Does methanol really dissolve silica during flash column chromatography?

      April 9, 2019 at 11:23 PM / by Bob Bickler posted in Developments, methanol, dichloromethane, dissolve


      This is an age-old question that has been around a long time, perhaps as long as me (and I have been around a while) –  “Does silica dissolve in methanol?”

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