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    When should I choose APCI or ESI for my flash column chromatography?

    February 11, 2020 at 3:16 PM / by Bob Bickler posted in mass spec, ESI, APCI

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    Mass spectrometers today are typically available with either Electrospray Ionization (ESI) or APCI (Atmospheric Pressure Chemical Ionization) sources.  That’s really nice but, how do you know which source will work best when purifying your sample?

    In this post I attempt to provide some guidance to selecting the ionization source best suited to your sample types.

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