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    Can dry load media choice impact normal-phase flash purification quality?

    June 2, 2021 at 4:28 PM / by Bob Bickler posted in Normal Phase, dry load, flash chromatography

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    Flash chromatography is a purification technique used by chemists to isolate their targeted compound from by-products and impurities. Because the reaction mixture (or natural product extract) may have its best solubility in a solvent that is chromatographically “stronger” than the mobile phase, liquid sample loading can be problematic causing early-eluting, broad peaks which can reduce purification efficacy and product purity. In those cases, a technique called dry loading is a better alternative.

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