Welcome to the new Flash Purification Blog from Biotage.

The value of in-line mass detection with flash column chromatography

December 11, 2018 at 7:56 PM / by Bob Bickler posted in flash purification, isolera, sfär

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For many chemists, flash chromatography with UV-triggered fractionation is part of their everyday workflow. Prior to flash chromatography, the reaction mixtures are either analyzed by TLC, analyzed by LC-MS, or both to ensure the targeted product has been synthesized. But, what if the reaction created a lot of by-products? How do you find your product in a sea of impurities? In this post, I will discuss how using a flash purification system with an in-line mass detector will simplify flash purification and isolate the target molecule or molecules. 

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How To Be Successful in Flash Chromatography

December 11, 2018 at 7:40 PM / by Bob Bickler posted in flash purification, Flash column chromatography, column chromatography lab

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On December 6th, 2018, Bob Bickler, Senior Technical Specialist, recorded a webinar on How To Be Successful with Flash Chromatography. To learn more, read the description below as well as watch the recording!

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Building greener separations into the flash workflow

November 20, 2018 at 3:01 PM / by Greg Saunders posted in flash purification, column chromatography method, greener flash purification, Flash column chromatography

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The synthesis of new chemical entities certainly has a high environmental cost due to the chemicals employed, especially in flash column chromatography, where large quantities of solvents are routinely used. The previous article in this series presented three strategies that can greatly reduce the environmental impact of your flash purifications: (1) purifying more product with less silica, and solvent, (2) making green chemistry work for you, such as changing to more environmentally friendly solvents, and (3) optimizing chromatography with more effective step gradients. Let’s look at how new developments in column design, simplifications in step gradients, and support from a leader in flash column chromatography can help in making your operation greener.

 

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Make researching new chemistries more fun with the right automated flash column chromatography system

November 5, 2018 at 10:00 AM / by John Urh posted in flash purification, automated chromatography system, column chromatography method, Flash column chromatography

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As we saw in a previous article, the most critical and time-consuming part of organic chemistry synthesis is the purification step. Running a column, testing the resulting fraction, and maybe re-running columns takes too much time – time you could use to prepare reactions or research new chemistries. What if your laboratory equipment made it easier for you to focus on amazing khemistry? Let’s find out what is possible with the latest in automated flash column chromatography systems. 
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Biotage® Selekt

October 1, 2018 at 1:18 PM / by Raffaella Bombarda posted in flash purification, automated chromatography system, column chromatography lab, Flash column chromatography, flash chromatography, workflow

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Konfidence With a Capital "K", That's Why I Selekt Biotage

The new Biotage® Selekt Flash Purification System is a system you can use with Konfidence. Purification is a fundamental step in discovery research and, as pioneers of automated flash purification, Biotage® is your ideal partner. Our core philosophies of Quality, Reliability and Environmentalism are drawn from our Swedish heritage. Our smart and intuitive design comes from our knowledge of what our customers need each day. You can see why our customers have “Konfidence” with a capital “ K” in our brand.When it comes to purification there are five reasons to Selekt Biotage®.
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Biotage® Sfär

October 1, 2018 at 1:17 PM / by Raffaella Bombarda posted in flash purification, column chromatography lab, silica column, column, greener column chromatography, flash chromatography

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Sfär Stands for Spherical, Biotage® Stands for Quality 

Biotage developed and introduced pre-packed columns for flash purification in 1994. Today our broad selection of columns enables professionals to choose the solution which best suits their purification needs.

Sfär is the Swedish word for "sphere", and the name of our columns reflects the fact that we have made spherical silica a standard due to its higher surface area and higher loading capacity. Reliable and flexible, Biotage® Sfär columns deliver larger loading capacities, tighter elution bands and purer fractions than traditional flash columns.
Biotage® Sfär is a complete portfolio of flash columns, available in a large variety of sizes from 5g to 350 g and in a range of media types, so you can purify milligrams to multi-grams of your valuable compounds quickly and easily.

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How tools such as flash column chromatography boost confidence in drug discovery

September 26, 2018 at 3:54 PM / by Kathryn Lawrence posted in column chromatography procedure, flash purification, pharmaceutical research, column chromatography lab, column chromatography method, silica column, automated chromatography system

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New drug substances, the result of more than a decade of pharmaceutical research and development,  have revolutionized society by saving lives, increasing life-spans, reducing suffering, avoiding surgery, and shortening hospital stays. New breakthroughs in the treatment of non-communicable diseases mean that drug substances are in a constant state of high demand, making the pharmaceutical industry one of the most innovative of industries on the globe. Why then, do so few drugs come to market? It turns out that a key factor is providing drug discovery chemists with tools such as automated flash chromatography to ensure that they can be confident in delivering target compounds in a timely fashion.

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Reducing Environmental Impact of Chemical Purification in Drug Discovery

August 28, 2018 at 7:44 PM / by Greg Saunders posted in flash purification, column chromatography, greener flash purification, greener column chromatography

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Chemistry, by its very nature, involves the use of chemicals that can be harmful, toxic and potentially damaging to the environment, which means that drug discovery currently has a large and expensive environmental footprint. However, all is not lost. With a few small steps it is possible to make a big change to the impact that drug discovery has on our world. Let’s look at ways we can reduce the environmental impact of chemical processing and flash chromatography. This involves using green chemistry applications in the purification workflow to find a solution that reduces chemical waste to make it good for both the chemist and the environment.

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