Chromatographic purification methods such as flash chromatography can have a high environmental impact since they typically involve large quantities of harmful or toxic solvents run at high flow rates. In many laboratories the cost of procuring and then disposing of these solvents can be a major part of the overall cost of projects. For the chemist, trying to reduce the environmental impact of small molecule synthesis is part of being a good global citizen. Here are three strategies that greatly reduce the environmental impact of flash purifications. It can also save money in the long run by reducing the cost of chemical waste disposal.