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    Does dry load media choice impact reversed-phase flash purification results?

    June 15, 2021 at 4:07 PM / by Bob Bickler posted in Reversed-phase, dry load, media

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    Flash chromatography is a purification technique used by chemists to isolate their targeted compound from by-products and impurities. Because the reaction mixture (or natural product extract) may have its best solubility in a solvent that is chromatographically “stronger” than the mobile phase, liquid sample loading can be problematic causing early eluting and/or broad peaks with poor purity. In those cases, a technique called dry loading is frequently used.

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