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    Can I use TLC for reversed-phase flash column chromatography method development?

    January 7, 2020 at 8:49 PM / by Bob Bickler posted in Reversed-phase, TLC, method development


    I am often asked why reversed-phase TLC data does not translate well to reversed-phase flash column chromatography.  There are several reasons for this and in this post I will attempt to explain the challenges associated with reverse-phase TLC as a method development tool for reversed-phase flash chromatography.

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