Welcome to the Biotage Flash Purification Blogs.

    How does reagent concentration impact synthesis?

    February 8, 2022 at 6:00 PM / by Bob Bickler posted in Solvents, Synthesis, microwave, concentration

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    As you know, reaction chemistry involves determining and selecting the right conditions for optimal product yield and purity. There are actually six variables, that I know of, needing consideration including…

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    How does reaction time impact synthetic product purity and yield?

    November 30, 2021 at 4:59 PM / by Bob Bickler posted in Reversed-phase, Normal Phase, microwave

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    For my purification blog I often will synthesize compounds so I can show representative, real-world reaction product purification. In doing so, I decided I would also post on the impact of various synthesis variable. This post looks at the impact of reaction temperature time on an amide synthesis.

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    How Can I Speed-up My Synthesis Workflow?

    October 20, 2020 at 2:04 PM / by Bob Bickler posted in Scavenger, V-10, Extraction method optimization, microwave, purification

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    Wouldn’t it be nice if your reactions only created your desired product? Of course the answer is yes, but that is not the reality of synthetic chemistry. Because our chemical reactions yield multiple components, they need work-up and purification to isolate the desired compound.

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    Can reaction solvent choice impact synthesis results?

    June 30, 2020 at 5:21 PM / by Bob Bickler posted in Synthesis, microwave

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    Most chemical reactions take place in liquid form since compounds in solution are more likely to interact with each other, especially when heated. Reaction solvent choice varies based on reagent solubility and reaction temperature requirements. Because many reactions today require high temperatures, solvents such as dimethylformamide (DMF) and dimethylsulfoxide (DMSO) are frequently used. However, just because a reaction solvent has the proper reagent solubility and/ or a high boiling point does not mean it should be used. Why? Well, as we will show in this post, the solvent itself can alter synthetic efficiency by changing reaction kinetics as well as the number and type of by-products.

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    Microwave synthesis in the teaching laboratory

    May 29, 2020 at 3:00 PM / by Greg Saunders posted in Initiator, microwave

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    In drug discovery, microwaves are common tools for heating reactions to high temperatures and pressures so that it is possible to synthesize compounds in minutes that might otherwise take hours by conventional heating. However, another environment where this is a considerable advantage is in the teaching laboratory. By greatly speeding reaction rates, students can try multi-step synthesis is a single day, and look at the effect of altering reaction conditions on products and yields.

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