Welcome to the Biotage Flash Purification Blogs.

      Six key factors that impact flash chromatography

      October 18, 2019 at 9:54 PM / by Bob Bickler posted in solvents, particle size, surface area, chemistry, flow rate


      In this post I will delve into six key factors that impact your purification success in flash column chromatography.

      Previously, I have discussed the use of TLC for solvent scouting and method development and optimization. I have have also talked about cartridge size, particle size, and surface area and their impact on flash purification.  Here I integrate that information into the six factors below.

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      Greener flash chromatography tips

      April 30, 2019 at 10:18 PM / by Bob Bickler posted in solvent, greener flash purification, particle size, surface area


      In our more environmentally aware climate, chemical and pharmaceutical companies now prioritize reducing organic solvent use in chemistry labs. Employees and shareholders alike are pushing their companies to become greener which impacts how chemistry, both synthesis and purification, is performed.

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      Are so-called “high performance” flash columns worth their higher prices?

      March 19, 2019 at 10:05 PM / by Bob Bickler posted in resolution, particle size, surface area


      Most flash column manufacturers now offer “high performance” flash chromatography columns with the promise of higher loading, increased purity, and even reduced solvent consumption. Working for Biotage, I have made those valid claims for our products as well.

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