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    How to prevent compound precipitation during flash column chromatography

    November 1, 2019 at 9:34 PM / by Bob Bickler posted in Peptides, Solvents


    Compounds precipitating during flash chromatography is at best an inconvenience when working up your crude reaction mixture.  Precipitation during purification typically happens in the column or in the tubing exiting the column.

    In this post, I will propose a strategy that can minimize and perhaps prevent this issue from occurring.

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