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    How does an acid pH affect reversed-phase chromatography separations?

    August 10, 2021 at 6:00 PM / by Bob Bickler posted in Reversed-phase, acid, pH

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    Chromatography is as much an art as it is a science. Between synthetic reaction products and natural products, the range of compounds requiring separation, purification, and isolation is broad and diverse creating challenges from time to time. Because of this diversity, not all chromatographic separations can be performed with a “neutral” solvent system – one without added pH modifiers or buffers.

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