This is a question I asked myself while I have been studying synthesis variables to see what, if any, impact each variable has on reaction product yield and purity. For this post, I evaluated the order in which I added reactants and solvent.

Chemical reactions gone wrong, I’m sure we all have experienced this issue, I know I have. You add your reagents in the proper amounts with a suitable solvent and perform your reaction only to find your by-product yield was greater than your product; by a lot. So, what do you do to isolate what little product you created with maximum yield and purity without breaking the proverbial bank on a big flash column and the solvent required for the purification?

I am always grateful for the feedback I get from my blog readers.  Today's blog is in response for multiple requests for tips on purifying complex mixtures and suggestions for alternative sample loading techniques.

In this post, I will attempt to address both, to some degree anyway, with a single example using a scavenger resin.