Welcome to the Biotage Flash Purification Blogs.

      When should I use dry loading instead of liquid loading with flash column chromatography?

      October 4, 2019 at 6:17 PM / by Bob Bickler posted in cartridge, Celite, chromatography, DCM, Developments, DMF, dry load, MAOS, microwave, polar, Samplet(R), silica, synthesis, workflow


      Many microwave assisted organic synthesis (MAOS) reactions use polar solvents such as alcohols, DMF, DMSO, because they absorb and transfer microwave energy very efficiently.  However, the downside of using polar, microwave absorbing solvents is that they can interfere with normal-phase flash chromatography.

      In this post, I discuss why dry loading can be advantageous when purifying polar-solvated reaction mixtures.

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      How many ways can you load sample on your column?

      May 31, 2019 at 4:02 PM / by Raffaella Bombarda posted in dry load, samplet, Samplet(R), flash chromatography, Flash column chromatography, column, silica column, flash purification, sfär, loading capacity


      Biotage®, a pioneer in Flash Purification, launched the unique, removable cap SNAP flash chromatography columns in 2007. This beneficial column design feature continues with the newest Biotage flash columns named Sfär columns.

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