Which solvents are best for terpene flash chromatography?
July 6, 2022 at 2:59 PM / by Bob Bickler posted in UV, selectivity
Which solvent is better for reversed-phase flash chromatography - methanol or acetonitrile?
January 26, 2021 at 1:49 PM / by Bob Bickler posted in Chromatography Fundamentals, acetonitrile, methanol, selectivity
An interesting question for synthesis chemists as the need for reversed-phase flash chromatography for both intermediates and final compounds increases. Historically, normal-phase flash chromatography has been the “go-to” purification tool for synthetic intermediates. Today, however, intermediates and final products are increasingly polar. These polar reaction mixtures cause purification challenges in both separation and recovery with normal-phase (silica) thus requiring use of reversed-phase flash chromatography.