Welcome to the Biotage Flash Purification Blogs.

    How does an acidic pH affect reversed-phase chromatography separations?

    November 1, 2022 at 2:19 PM / by Bob Bickler posted in Reversed-phase, flash chromatography, separation

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    Chromatography is as much an art as it is a science. Between synthetic reaction products and natural products, the range of compounds requiring separation, purification, and isolation is broad and diverse creating challenges from time to time. Because of this diversity, not all chromatographic separations can be performed with a “neutral” solvent system – one without added pH modifiers or buffers.

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    How important is flow rate in flash chromatography?

    August 9, 2022 at 1:54 PM / by Bob Bickler posted in flow rate, separation, linear velocity

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    I often get questions from customers about the influence of flow rate on their flash chromatography. Typically, the questions are…

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