Welcome to the Biotage Flash Purification Blogs.

    Why does my silica flash chromatography column get hot?

    December 23, 2020 at 3:16 PM / by Bob Bickler posted in silica, heat


    Silica is the most commonly used sorbent for flash column chromatography. When solvent is pumped through a column packed with dry silica you may notice it gets warm and sometimes down right hot!

    In this post I will attempt to explain why this phenomena occurs.

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    Why Reusing Flash Cartridges is Bad Science

    December 14, 2020 at 10:08 AM / by Bob Bickler posted in Reuse, silica


    For many chemists lab budgets, especially for consumable items, are limited.  One way of trying to stretch their lab budget is to reuse disposable flash chromatography cartridges.

    In this post I will show how regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and fraction purity.

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