Welcome to the Biotage Flash Purification Blogs.

    Why does my silica flash chromatography column get hot?

    December 23, 2020 at 3:16 PM / by Bob Bickler posted in silica, heat

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    Silica is the most commonly used sorbent for flash column chromatography. When solvent is pumped through a column packed with dry silica you may notice it gets warm and sometimes down right hot!

    In this post I will attempt to explain why this phenomena occurs.

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    Why Reusing Flash Cartridges is Bad Science

    December 14, 2020 at 10:08 AM / by Bob Bickler posted in Reuse, silica

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    For many chemists lab budgets, especially for consumable items, are limited.  One way of trying to stretch their lab budget is to reuse disposable flash chromatography cartridges.

    In this post I will show how regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and fraction purity.

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