Welcome to the Biotage Flash Purification Blogs.

    When do I need to use an ELSD with flash chromatography?

    May 11, 2022 at 2:16 PM / by Bob Bickler posted in Detector, UV, elsd

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    Flash chromatography can be complex. Solvent choice, column size, stationary phase, loading technique, gradient method, flow rate, and detection parameters are all variables which factor into flash chromatography and your success with this purification technique. Of these variables, detection parameters, i.e. the type of detector, can really impact your flash chromatography results.

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    How can flash chromatography UV absorbance spectra be used to identify purified compounds?

    August 25, 2020 at 1:52 PM / by Bob Bickler posted in Chromatography Fundamentals, UV, Spectra

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    As chemists, our job is to make new molecules. If our synthetic design works as planned, we will have success and the target product made. As we all know, along with our desired compound, by-products are often created as well. To remove the by-products, the reaction mixture requires purification, typically with flash chromatography.

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