Welcome to the Biotage Flash Purification Blogs.

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How to improve synthesis workflow by over 90%

How to create a reversed-phase step gradient

What is the smallest amount I can purify using flash chromatography?

Why is Solvent Evaluation by TLC Important for Good Flash Chromatography Results?

How does a flash system’s internal volume affect gradients?

How does an acidic pH affect reversed-phase chromatography separations?

How should I make my linear gradient?

What is a step gradient and why should I use it?

How does acid concentration impact reversed-phase flash chromatography?

How important is flow rate in flash chromatography?

Which solvents are best for terpene flash chromatography?

How to maximize UV detection sensitivity in flash chromatography

How to isolate impurities from a reaction product

How to avoid sample blowback when liquid loading

Do It Yourself: Flash Chromatography Test Mix

When do I need to use an ELSD with flash chromatography?

Is reversed-phase flash chromatography less expensive than normal-phase?

What is the maximum flash column sample load volume?

When is Gradient Elution Better than Isocratic Elution?

How should normal-phase gradient solvents be chosen?

How many times can I reuse my reversed-phase flash column?

How does reagent concentration impact synthesis?

When Should I Replace My Flash C18 Column?

How Scalable is Flash Chromatography?

How does reaction time impact synthetic product purity and yield?

Can Reaction Temperature Impact Synthetic Product Yield and Purity?

Does reagent and reaction solvent order impact product yield and purity?

Can maximizing product yield and purity from messy reaction mixture be green?

Can water be used as an organic synthesis solvent?

What is Orthogonal Flash Chromatography and Why Should I do it?

What are alternatives to DCM/MeOH for polar reaction mix purifications?

How does an acid pH affect reversed-phase chromatography separations?

Does Detection Wavelength Influence Compound Purity and Recovery?

Does dry load media choice impact reversed-phase flash purification results?

Can dry load media choice impact normal-phase flash purification quality?

What is the maximum volume I can load on my reversed-phase flash column?

What is my C18 flash column's loading capacity?

Does flash column equilibration volume impact purification results?

How can I dry my temperature-sensitive product without degradation?

What is the best way to purify a crude reaction mixture that auto-crystallizes?

How to Purify your Target Compound with Minimal Impurities

How does gradient slope impact flash chromatography loading capacity?

Which solvent is better for reversed-phase flash chromatography - methanol or acetonitrile?

TLC-based vs. Generic Gradients – Which Gives the Best Results?

Can Flash Chromatography be Green? Part 1

Can Flash Column Chromatography be Green? Part 2

When should I use a “high-performance" flash chromatography column?

Why is TLC Rf important for flash column chromatography optimization?

Why does my silica flash chromatography column get hot?

Which sample solvents work best with normal-phase flash column chromatography?

What impact do buffers have on APCI mass detection?

Using adducts and fragments to identify compounds in mass-directed flash chromatography

Why Reusing Flash Cartridges is Bad Science

In-line mass detection to find the undetectable in flash column chromatography

Using pH to optimize reversed-phase flash chromatography separations

Does mass detection make-up solvent choice matter?

Can reversed-phase flash column chromatography be greener?

Detecting the undetectable in flash column chromatography, part 2

Does high performance flash column chromatography require high performance TLC for method development?

When should I add acid to my detector make-up solvent when using mass-directed flash chromatography?

In-line Scavenging Simplifies Flash Column Chromatography Reaction Mixture Purification

Can reversed-phase chromatography compound elution volume/time be predicted?

Invest 10 minutes on TLC and save a day of grief

Why is my UV baseline changing during flash column chromatography?

How does media pore size impact small-molecule flash column chromatography?

Non-aqueous (or nearly so) reversed-phase flash column chromatography – a nice alternative for purifying lipophilic compounds

How Can I Speed-up My Synthesis Workflow?

Ionizable compound purification using reversed-phase flash column chromatography

How best to extract reaction products from high boiling solvents

How can flash chromatography UV absorbance spectra be used to identify purified compounds?

How should I purify a complex, polar, amide reaction mixture?

How do I convert my HPLC method to flash chromatography?

Can reaction solvent choice impact synthesis results?

Microwave synthesis in the teaching laboratory

When should I use an amine-bonded silica for flash chromatography?

How do I scale-up my reversed-phase flash chromatography method?

This might actually be a good time to choose a reliable partner

5 Steps to successful flash chromatography

Does a longer flash column really provide better purification?

Biotage Selekt in Polymer Material Research at Konstanz University

Understanding silica – why matching TLC and flash silica is important for good flash column chromatography

How and when to insert an isocratic hold in flash column chromatography

How do I remove an annoying MS TIC background?

Scaling up chromatography to the manufacturing plant

How does an alkaline pH affect normal-phase flash chromatography separations?

What is the Chemistry Behind Reversed-Phase Flash Chromatography?

What is the Chemistry Behind Normal-Phase Flash Chromatography?

When should I choose APCI or ESI for my flash column chromatography?

When should I use a pH modifier in flash column chromatography gradient?

How can I modify my flash chromatography method to separate chemically similar compounds?

What do I do if a 2-solvent gradient will not separate my sample?

Flash system UV detectors – similarities and differences

Why do I see more peaks than I expect with flash column chromatography?

So, how does an ELSD work?

5 Tips on extending reversed-phase flash chromatography cartridge life

Can I use TLC for reversed-phase flash column chromatography method development?

Does Size Really Matter in Flash Chromatography? Part 2

Does size really matter in flash chromatography? Part 1

So, which detector should I use for flash column chromatography?

How do I decide between normal- or reversed-phase flash column chromatography?

Are there advantages to stacking flash chromatography columns?

Are reversed-phase flash chromatography columns designed for aqueous solvents necessary?

Pushing flash column chromatography loading limits

Green Flash Chromatography Webinar

How do I purify ionizable organic amine compounds using flash column chromatography?

Does particle shape and/or particle size impact flash column chromatography load limits?

Why can’t I reproduce my TLC separation using flash column chromatography?

How does mobile phase organic solvent choice impact reversed-phase flash column chromatography?

How many times can I reuse my flash chromatography column?

How Much Is My Flash Chromatography System Really Going to Cost?

Organic Chemistry Workflow – Typical Steps and Equipment

The Step Gradient Explained

How to prevent compound precipitation during flash column chromatography

What is the optimal sample to sorbent ratio for dry loading in flash column chromatography?

Flash column equilibration – is it a waste of time or necessary step?

Why are my flash column chromatography peaks splitting?

How important is your flash column’s plate count, aka efficiency, to your purification?

Biotage vs Biotage, and the winner is...

California State University Increases Productivity with Selekt

How Sfär Impacted Column use at the University of North Carolina Chapel Hill

Which sorbents work best for dry loading flash column chromatography samples?

Purifying ionic compounds by flash column chromatography

Six key factors that impact flash chromatography

How do I purify my high boiling solvent reaction mixture using silica flash chromatography?

How does solvent choice impact flash column chromatography performance?

Prep HPLC vs. reversed-phase flash chromatography: How to choose?

How does solvent choice impact reversed-phase flash chromatography separations?

How do I choose between Normal- or Reversed-phase flash column chromatography for my compound purification?

Acetone – a lower cost alternative to EtOAc in normal-phase flash column chromatography

When should I use dry loading instead of liquid loading with flash column chromatography?

Detecting the undetectable in flash column chromatography using wavelength focusing

What is a Chromatography Gradient?

Which injection solvents should I use for reversed-phase flash purification?

Using TLC to Scout Flash Chromatography Solvents

How do I Create an Efficient Gradient Flash Chromatography Method?

Very polar compound purification using aqueous normal-phase flash column chromatography

Preparation and use of an internal dry loading device for flash chromatography

What is Flash Chromatography and why should I do it?

What are good reversed-phase dry load options?

Setting the Right Flow Rate for Flash Column Chromatography

Which loading method should I use for purification by flash chromatography?

How do I determine loading capacity in reverse phase flash column chromatography?

How do I develop a reversed-phase flash column chromatography method?

How to minimize particulate build-up in flash chromatography systems

A Workflow for Academic Drug Discovery - Baylor University Customer Case

How much DMF or DMSO can I inject on my reversed-phase flash chromatography column?

How do I Choose the Right Column Size for Purification by Flash Chromatography?

Benefits of acetonitrile over methanol in normal-phase flash column chromatography

How to Optimize TLC to Enhance Purification by Flash Chromatography

How changing stationary phase chemistry can impact separation selectivity

How many ways can you load sample on your column?

Dry loading media options – diatomaceous earth

How can I perform normal-phase and reversed-phase column chromatography on one flash system?

Can reversed-phase flash chromatography purify better than normal-phase?

How can I reduce flash column purification time and cost?

Determining solvent strength in flash column chromatography

How do particle size and flow rate affect normal-phase flash column chromatography

Greener flash chromatography tips

Increasing Productivity with Automated Flash Purification - Rice University Customer case

How to Choose Between Linear Gradients and Step Gradients for Flash Chromatography

Is there an easy way to purify organic amines?

So, what exactly is a column volume in flash column chromatography and how is it determined?

Does methanol really dissolve silica during flash column chromatography?

Flash column chromatography equilibration speed – how fast can you go?

Packing a column is part science and part art...and Biotage has both

Let your worries evaporate...it's never been so easy!

Walk-up, Walk away Evaporation System

All you want to know about evaporation...and never dared to ask

Why is reversed-phase flash chromatography use increasing?

Are so-called “high performance” flash columns worth their higher prices?

Webinar: A Roadmap to Successful Chromatography

The three reasons you should be using step gradients for flash column chromatography

Which dry load sorbent should I use for flash column chromatography?

Does your crude sample/sorbent dry load ratio impact flash column chromatography results?

Are you in control of your Flash Purification?

Dry loading vs. liquid loading, which provides better flash column chromatography results?

Are there benefits to collecting flash chromatography fractions based on multiple UV wavelengths?

The value of in-line mass detection with flash column chromatography

Webinar: Inspiring Productivity with Modern Flash Chromatography

This is how you can use Biotage Sfär columns on your Isolera

Building greener separations into the flash workflow

Make researching new chemistries more fun with the right automated flash column chromatography system

Confidence in dependable vendors helps chemists achieve a step-change in flash chromatography purification

Kontrolling purification outcomes from flash column chromatography

Be creatively produKtive with knowledge and the right flash chromatography system

Biotage® Selekt

Biotage® Sfär

How tools such as flash column chromatography boost confidence in drug discovery

Reliable purification systems from dependable vendors accelerate drug discovery

Automated flash column chromatography helps to make chemistry more fun

Automated flash column chromatography frees up time to enjoy researching new chemistries

How to boost productivity when using flash column chromatography

Five creative ways to increase productivity in organic synthesis

Get control of flash column chromatography and purify your compound first time

How to work smarter with flash column chromatography

Reducing Environmental Impact of Chemical Purification in Drug Discovery

Three Key Strategies that make Flash Purification Greener

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About Biotage

Biotage is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in Drug Discovery and Development, Analytical Testing and Water and Environmental Testing.

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