For most chemists, flash purification is a means to an end. In other words, it is a tool needed to purify and isolate one compound from a mixture of compounds so that the next reaction can occur with reduced by-product formation. Other than choosing between normal- or reversed-phase, there typically is not much thought put into cartridge selection, especially not related to stationary phase media porosity.
For most small molecules, this approach makes sense, but for larger molecules and very lipophilic compounds, factoring for media porosity should be included. In this post, I will discuss the impact media porosity can have on chromatographic performance.