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Can water be used as an organic synthesis solvent?

September 23, 2021 at 2:28 PM / by Bob Bickler



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What is Orthogonal Flash Chromatography and Why Should I do it?

September 7, 2021 at 3:15 PM / by Bob Bickler


Think of orthogonal flash chromatography as 2D-chromatography where a reaction mixture or natural product extract is purified first with one methodology or solvent gradient then re-purified with a different method or solvent pair in order to remove co-eluting impurities. This is a technique practiced in medicinal chemistry, especially for final compound purification, when the final product is purified first with normal-phase flash followed by reversed-phase prep HPLC.

There are two general flash chromatography techniques...

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