Welcome to the new Flash Purification Blog from Biotage.

Bob Bickler


Recent Posts

The value of in-line mass detection with flash column chromatography

December 11, 2018 at 7:56 PM / by Bob Bickler posted in flash purification, isolera, sfär

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For many chemists, flash chromatography with UV-triggered fractionation is part of their everyday workflow. Prior to flash chromatography, the reaction mixtures are either analyzed by TLC, analyzed by LC-MS, or both to ensure the targeted product has been synthesized. But, what if the reaction created a lot of by-products? How do you find your product in a sea of impurities? In this post, I will discuss how using a flash purification system with an in-line mass detector will simplify flash purification and isolate the target molecule or molecules. 

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How To Be Successful in Flash Chromatography

December 11, 2018 at 7:40 PM / by Bob Bickler posted in flash purification, Flash column chromatography, column chromatography lab

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On December 6th, 2018, Bob Bickler, Senior Technical Specialist, recorded a webinar on How To Be Successful with Flash Chromatography. To learn more, read the description below as well as watch the recording!

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Get control of flash column chromatography and purify your compound first time

September 5, 2018 at 4:57 PM / by Bob Bickler posted in flash chromatography, Flash column chromatography, column chromatography

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Organic reactions are generally inefficient, which means that crude reaction mixtures require work-up and purification to remove by-products and unreacted starting materials and/or catalysts. The goal in pharmaceutical research is to isolate the target compound with required purity and yield to be able to progress to the next synthetic sequence or biological testing with confidence. But the process of purification is viewed by synthetic chemists as a ‘means-to-an-end’ and the more rapidly and reliably the purification step can be performed the better. Easy enough to state, but hard to achieve when you need to be certain of purity and yield in a single, rapid purification attempt. As we will see here, flash column chromatography can help you achieve this.

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How to work smarter with flash column chromatography

September 5, 2018 at 4:54 PM / by Bob Bickler posted in flash chromatography, Flash column chromatography, greener column chromatography

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First, join me on a flashback to my past as a discovery chemist just fresh out of grad school and eager to make a difference in pharmaceutical research. I was advised by my boss to model my behavior after a colleague and labmate with a reputation of being highly productive and successful. I was also informed that ‘chemist productivity’ was measured by 1) the number of compounds (of sufficient quantity and quality) he/she registered in the company’s database and 2) meeting project milestones.

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