Welcome to the new Flash Purification Blog from Biotage.

Greg Saunders


Recent Posts

Building greener separations into the flash workflow

November 20, 2018 at 3:01 PM / by Greg Saunders posted in flash purification, column chromatography method, greener flash purification, Flash column chromatography

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The synthesis of new chemical entities certainly has a high environmental cost due to the chemicals employed, especially in flash column chromatography, where large quantities of solvents are routinely used. The previous article in this series presented three strategies that can greatly reduce the environmental impact of your flash purifications: (1) purifying more product with less silica, and solvent, (2) making green chemistry work for you, such as changing to more environmentally friendly solvents, and (3) optimizing chromatography with more effective step gradients. Let’s look at how new developments in column design, simplifications in step gradients, and support from a leader in flash column chromatography can help in making your operation greener.

 

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Reducing Environmental Impact of Chemical Purification in Drug Discovery

August 28, 2018 at 7:44 PM / by Greg Saunders posted in flash purification, column chromatography, greener flash purification, greener column chromatography

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Chemistry, by its very nature, involves the use of chemicals that can be harmful, toxic and potentially damaging to the environment, which means that drug discovery currently has a large and expensive environmental footprint. However, all is not lost. With a few small steps it is possible to make a big change to the impact that drug discovery has on our world. Let’s look at ways we can reduce the environmental impact of chemical processing and flash chromatography. This involves using green chemistry applications in the purification workflow to find a solution that reduces chemical waste to make it good for both the chemist and the environment.

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Three Key Strategies that make Flash Purification Greener

August 28, 2018 at 7:34 PM / by Greg Saunders posted in flash chromatography, greener column chromatography, greener purification, greener flash purification

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Chromatographic purification methods such as flash chromatography can have a high environmental impact since they typically involve large quantities of harmful or toxic solvents run at high flow rates. In many laboratories the cost of procuring and then disposing of these solvents can be a major part of the overall cost of projects. For the chemist, trying to reduce the environmental impact of small molecule synthesis is part of being a good global citizen. Here are three strategies that greatly reduce the environmental impact of flash purifications. It can also save money in the long run by reducing the cost of chemical waste disposal.

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