Welcome to the new Flash Purification Blog from Biotage.

John Urh


Recent Posts

Make researching new chemistries more fun with the right automated flash column chromatography system

November 5, 2018 at 10:00 AM / by John Urh posted in flash purification, automated chromatography system, column chromatography method, Flash column chromatography

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As we saw in a previous article, the most critical and time-consuming part of organic chemistry synthesis is the purification step. Running a column, testing the resulting fraction, and maybe re-running columns takes too much time – time you could use to prepare reactions or research new chemistries. What if your laboratory equipment made it easier for you to focus on amazing khemistry? Let’s find out what is possible with the latest in automated flash column chromatography systems. 
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Be creatively produKtive with knowledge and the right flash chromatography system

October 10, 2018 at 2:35 PM / by John Urh posted in Flash column chromatography, flash chromatography

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I think that the phrase ‘creative productivity’ captures the essence of an organic chemist’s work. It’s not about the number of new molecules produced per day at all. Creative organic chemists have much more in common with prolific artists and craftspeople. Prolific chemists are relentless discoverers of synthetic pathways that result in a stream of new molecules in, for example, pharmaceutical research. Being prolific involves dealing with the complexities of synthetic pathways, completing projects, and strategizing the next steps once the SAR study results are in. Increasing productivity involves knowledge, and applying it, using the right tools.

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Automated flash column chromatography helps to make chemistry more fun

September 19, 2018 at 11:12 AM / by John Urh posted in Flash column chromatography, flash chromatography, column chromatography, column chromatography procedure, pharmaceutical research, column chromatography method, silica column, automated chromatography system

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Isn’t amazing chemistry what you want to do every day? Don’t you strive for white crystalline final products? But things get in the way, such as other priorities, endless emails and frequent interruptions to your synthetic flow.  Not to mention the challenges of designing new synthetic strategies, creating what could be the world’s most impactful new molecular entity. Finding the right reaction, the right reagents. Finding a way to get around yet another dead end. But those challenges are why you got into chemistry in the first place, right? After all, if it was easy, anyone could do it and you’re not just anyone. So let’s look at a few things that can put the fun back into chemistry.

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Automated flash column chromatography frees up time to enjoy researching new chemistries

September 19, 2018 at 11:09 AM / by John Urh

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Our recent survey of organic synthetic chemists showed that more than half of you feel that the most enjoyable aspect of your work is researching new chemistries, while 33% told us that preparing reactions was the best part of your day. Purifying products and writing up came in at distant 3rd and 4th places, and no one enjoyed doing work up. Sounds familiar? If you want to find out more about how to bring fun back into your chemistry then read on.

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How to boost productivity when using flash column chromatography

September 12, 2018 at 10:37 PM / by John Urh posted in flash chromatography, Flash column chromatography

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OK. We get it. You aren’t a molecule factory. Creating the right target molecule as soon as possible in order to keep your pharmaceutical research project moving isn’t easy or routine. Frankly, organic chemistry is hard and unpredictable. As Professor Gilbert Stork said, “Unless the molecule is very simple, it is not possible to go into the lab and make it within a short period of time.” His ‘Rule of Seven’ meant that, “however long you think a synthesis will take, multiply it by seven”.1

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Five creative ways to increase productivity in organic synthesis

September 12, 2018 at 10:36 PM / by John Urh posted in flash chromatography, Flash column chromatography

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Creative productivity

Creative productivity is the ability to find innovative ways to keep projects moving forward, including finding a way around the roadblocks that will inevitably show up as you go. So the real measure of productivity is not in molecules per day, but in your ability to find the synthetic pathway. Instrument manufacturers tend to want to tell you about the latest user-friendly ultra-fast instrument. Faster is nicer, but if you can cut 30 seconds off a column chromatography step, what does it matter when the reaction refluxed overnight and the reaction didn’t work? The thing is, many of the reliable techniques you apply to your organic chemistry work are considered unchangeable. There may be a better way, but that takes time and feels risky. So, you continue on, using what you learned as far back as college chemistry.

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