Peptides, while exhibiting potential for unique specificity and affinity, still suffer from stability issues when introduced to a biological system. One strategy to overcome these stability issues is include a covalent bond, creating a peptide macrocycle.
Many strategies have been reported for cyclizing peptides in the recent literature, however information that enables transitioning those published protocols for an automated process may be limited. The webinar below describes an optimization process for several common cyclization chemistries with the ultimate goal of automating the total synthesis process.
To learn more about the orthogonal deprotection strategies briefly mentioned herein, follow the link below.