Elizabeth Denton, PhD, Senior Scientist Peptide Chemistry, recorded a webinar titled Disulfide Rich Peptides: Optimizing and Automating Syntheses with Regioselective Formation of Disulfide Bonds. To learn more, read the description below as well as watch the recording!
Disulfide rich peptides (DRP) offer unique stability and plasticity when considering scaffolds for peptide-based therapeutics. With the recent FDA approval of Linaclotide, a 14 amino acid peptide with three disulfide bonds for the treatment of Irritable Bowel Syndrome, exemplifies the utility of this peptide class. While the linear synthesis of these peptides can be relatively straightforward, ensuring that the proper disulfide bond pattern is achieved reproducibly can be difficult but is absolutely critical for a successful discovery effort to proceed forward.
In this event we’ll demonstrate strategies to synthesize peptides containing one, two, or three disulfide bonds with regioselective control simplfied by the Initatior+ Alstra™ Branches™ software.